1. Signaling Pathways
  2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor

Aryl Hydrocarbon Receptor

Aryl Hydrocarbon Receptor (AhR or AHR or ahr or ahR) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic (aryl) hydrocarbons, and regulates xenobiotic-metabolizing enzymes such as cytochrome P450s, most notably cyp 1A1.

Aryl Hydrocarbon Receptor is a member of the family of basic helix-loop-helix transcription factors. AhR binds several exogenous ligands including natural plant flavonoids, polyphenolics and indoles, as well as synthetic polycyclic aromatic hydrocarbons and dioxin-like compounds. AhR is a cytosolic transcription factor that is normally inactive, binding to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription.

Aryl Hydrocarbon Receptor 相关产品 (15):

Cat. No. Product Name Effect Purity
  • HY-15484
    Pifithrin-α hydrobromide Agonist 98.28%
    Pifithrin-α hydrobromide是 p53 抑制剂,可阻断其转录活性并阻止细胞凋亡。Pifithrin-α hydrobromide 同时为 aryl hydrocarbon receptor (AhR) 的激动剂。
  • HY-12684
    CH-223191 Antagonist 98.16%
    CH-223191是有效且特异性的芳烃受体(AhR) 拮抗剂。 CH-223191阻断TCDD与AhR的结合,IC50 为0.03 µM。
  • HY-15001
    StemRegenin 1 Antagonist 99.50%
    StemRegenin 1 是一种有效的芳香烃受体 (AhR) 拮抗剂,IC50 为 127 nM。
  • HY-12451
    FICZ Agonist 98.19%
    FICZ是有效的芳烃受体 (AhR) 激动剂,Kd值为70 pM。
  • HY-104026
    L-Kynurenine Agonist 99.40%
    L-Kynurenine是L-色氨酸的代谢物。它是一种芳香烃受体 (aryl hydrocarbon receptor) 激动剂。
  • HY-102023
    GNF351 Antagonist 99.90%
    GNF351 是一种芳基烃受体 (AHR) 拮抗剂。GNF351 与结合到 AHR 的光亲和性 AHR 配体竞争,IC50 为 62 nM。GNF351 对小鼠或人角质形成细胞的毒性极小。
  • HY-W007355
    Skatole Activator >98.0%
    Skatole 是肠道菌群产生的物质,通过激活芳基烃受体 (aryl hydrocarbon receptors) 和 p38 调节肠上皮细胞功能。
  • HY-19317
    ITE Agonist 99.27%
    ITE 是一种有效的内源性芳香烃受体 (AhR) 激动剂,能够直接与 AHR 结合,Ki 值为 3 nM。ITE 具有免疫抑制作用。
  • HY-N0178
    Diosmin Agonist >98.0%
    Diosmin 是在各种柑橘类水果中发现的类黄酮,也是芳烃受体 (AhR) 的激动剂。
  • HY-N0170
    Indole-3-carbinol Agonist >98.0%
    Indole-3-carbinol (I3C) 是芳烃受体 (AhR) 的激动剂。
  • HY-112629
    PDM2 Antagonist 98.88%
    PDM2 是一种选择性的高亲和力芳烃受体 (AhR) 拮抗剂,Ki 为 1.2±0.4 nM。
  • HY-109044
    Tapinarof Agonist 99.74%
    Tapinarof 是一种天然的芳烃受体 (AhR) 激动剂,EC50 为 13 nM。
  • HY-112627
    CAY 10465 Agonist 98.48%
    CAY 10465 是一种选择性的,高亲和性的芳香烃受体 (AhR) 激动剂,Ki 值为 0.2 nM,对雌激素受体 (estrogen receptor) 无作用 (Ki >100000 nM)。
  • HY-111441
    1,4-Chrysenequinone Activator
    1,4-Chrysenequinone 是一种多环芳香烃类,可以作为芳香烃受体 (AhR) 的激活剂起作用。
  • HY-100242
    Mivotilate Activator >98.0%
    Mivotilate 是一种非毒性的,有效的芳烃受体 (aryl hydrocarbon receptor) 激动剂,具有护肝作用。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

江苏快三 江苏快3 江苏快三 江苏快3 江苏快三 江苏快三 江苏快3 江苏快三 江苏快三 江苏快三