1. Signaling Pathways
  2. Immunology/Inflammation
  3. PD-1/PD-L1

PD-1/PD-L1

Programmed death-1 (PD-1) is a receptor on T cells that has been shown to suppress activating signals from the T cell receptor when bound by either of its ligands, Programmed death-ligand 1 (PD-L1) or PD-L2。 When PD-1 expressing T cells contact cells expressing its ligands, functional activities in response to antigenic stimuli, including proliferation, cytokine secretion, and cytotoxicity are reduced。 PD-1/PD-Ligand interactions down regulate immune responses during resolution of an infection or tumor, or during the development of self tolerance。

Interference with the PD-1/PD-L1 interaction has also shown enhanced T cell activity in chronic infection systems。 Chronic lymphocytic chorio meningitis virus infection of mice also exhibits improved virus clearance and restored immunity with blockade of PD-L1。

In addition to enhancing immunologic responses to chronic antigens, blockade of the PD-1/PD-L1 pathway has also been shown to enhance responses to vaccination, including therapeutic vaccination in the context of chronic infection.

PD-1/PD-L1 相关产品 (14):

Cat. No. Product Name Effect Purity
  • HY-19745
    BMS-202 Inhibitor 99.37%
    BMS-202 是 PD-1/PD-L1 相互作用抑制剂,主要用于抗癌研究。
  • HY-19991
    BMS-1 Inhibitor 99.61%
    BMS-1 是 PD-1/PD-L1 蛋白质/蛋白质相互作用的抑制剂,IC50 为 6 到 100 nM。
  • HY-P9904
    Atezolizumab Inhibitor 98.98%
    Atezolizumab 是一种人源化单克隆抗体 IgG1,抵抗程序性死亡因子配体1 (PD-L1),用于癌症研究。
  • HY-P9903
    Nivolumab Inhibitor 98.56%
    Nivolumab 是一种 PD-1 抗体类抑制剂,用于晚期(转移性)非小细胞肺癌的研究。
  • HY-101093
    PD-1-IN-1 Inhibitor 98.48%
    PD-1-IN-1是PD-1的抑制剂, 来自专利WO 2015033299 A1,化合物实例4。
  • HY-101097A
    PD-1-IN-17 TFA Inhibitor
    PD-1-IN-17 TFA 是一种有效的程序性细胞死亡-1 (PD-1) 抑制剂,详细信息请参考专利文献 WO2015033301A1 中的化合物 12,浓度为 100 nM 时抑制 92% 脾细胞增殖。
  • HY-101097
    PD-1-IN-17 Inhibitor
    PD-1-IN-17 是一种有效的程序性细胞死亡-1 (PD-1) 抑制剂,详细信息请参考专利文献 WO2015033301A1 中的化合物 12,浓度为 100 nM 时抑制 92% 脾细胞增殖。
  • HY-101093B
    PD-1-IN-20 Inhibitor
    PD-1-IN-20 是 PD-1 的抑制剂。
  • HY-P9902
    Pembrolizumab Inhibitor 98.56%
    Pembrolizumab 是一种人源化抗体,为 PD-1 的抑制剂,用于癌症免疫的研究。
  • HY-108730
    Avelumab Inhibitor
    Avelumab 是一个人 IgG1 抗 PD-L1 单克隆抗体,具有潜在的抗体依赖性细胞介导的细胞毒性作用。
  • HY-102011
    BMS-1166 Inhibitor 99.79%
    BMS-1166 是 PD-1/PD-L1 相互作用的有效抑制剂,其 IC50 值为 1.4 nM。
  • HY-B0333
    Sulfamethizole Inhibitor 99.71%
    Sulfamethizole是磺胺噻唑类抗生素,能抑制细菌的PABA。
  • HY-B1387
    Sulfamethoxypyridazine Inhibitor 99.01%
    Sulfamethoxypyridazine是一种长效磺胺类药物, 用于治疗疱疹性皮炎。
  • HY-101098
    PD-1-IN-18 Inhibitor
    PD-1-IN-18 是 PD1 信号通路抑制剂,是一种免疫调节剂。
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