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  3. Galectin

Galectin

Galectins are a family of proteins that possess β-galactoside-binding properties through their carbohydrate recognition domains (CRDs). Galectins can be secreted from cells by nonclassic pathways to interact with external glycoconjugates and have a variety of activities both extra- and intracellularly, with important implicated roles in immunity, inflammation, and cancer.

Galectins can be classified according to the CRD features. Galectin-1, -2, -5, -7, -10, -11, -13, and -14 are composed of a CRD and a short N-terminal sequence (prototype). Galectin-4, -6, -8, -9, and -12 have two nonidentical CRDs in tandem with a short linker sequence (tandem-repeat type). Galectin-3 has an exceptional structure, with a CRD and an extended N-terminal domainconsisting of gycine/proline-rich repeats and a short N-terminal end (chimera type). Galectin-1 (Gal1), a carbohydrate-binding protein is implicated in cancer cell proliferation, invasion and tumour angiogenesis. Galectin-3 (Gal3) is a β-galactoside binding lectin that is highly expressed in fibrotic tissue of diverse etiologies.

Galectins have emerged as key players in the tumor microenvironment。 Galectins are expressed and released by different celltypes, including tumor, stromal, endothelial and immune cells。 Galectins critically influence tumor progression by modulating tumor cell migration, invasiveness, angiogenesis and antitumor immune responses。 Intracellularly, galectins modulate survival and proliferation and they interact with a variety of signaling pathways。 Given these extracellular and intracellular functions and their regulated expression at sites of tumor growth and metastasis, galectins have stimulated great interest as relevant biomarkers and novel targets in cancer therapy。

Galectin 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-19940
    TD139 Inhibitor 99.39%
    TD139是吸入式的半乳凝素-3 (galectin-3) 抑制剂,Kd 值为14 nM。
  • HY-19756
    OTX008 Inhibitor 99.36%
    OTX008 是一个半乳糖凝集素 1 (galectin-1) 的选择性抑制剂。
  • HY-P1592A
    G3-C12 TFA 99.44%
    G3-C12 (TFA) 是 galectin-3 结合肽,Kd 值为 88 nM,具有抗肿瘤活性。
  • HY-P1592
    G3-C12
    G3-C12 是 galectin-3 结合肽,Kd 值为 88 nM,具有抗肿瘤活性。
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